Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA

Influence of Disulfide Connectivity on Structure and Bioactivity of α-Conotoxin TxIA

Cone snails express a sophisticated arsenal of small bioactive peptides known as conopeptides or conotoxins (CTxs). Through evolutionary selection, these peptides have gained the ability to interact with a range of ion channels and receptors, such as nicotinic acetylcholine receptors (nAChRs). Here,...

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Bibliographic Details
Main Authors: Yong Wu, Xiaosa Wu, Jinpeng Yu, Xiaopeng Zhu, Dongting Zhangsun, Sulan Luo
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Molecules
Subjects:
α-conotoxin TxIA
α3β2 nAChRs
disulfide isomerisation
peptide synthesis
oxidative folding
Online Access:http://www.mdpi.com/1420-3049/19/1/966

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http://www.mdpi.com/1420-3049/19/1/966

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