High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy

High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy

Numerous risk factors for heart disease or dementia harbor over 10% valine plus glycine content. Interestingly, TDP-43 contains 6.0% valine and 13.3% glycine, and the buildup of this protein in the brains of patients with limbic-predominant age-related TDP-43 encephalopathy has dire consequences. Th...

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Bibliographic Details
Main Authors: Shanshan An, Xiaoxiao Zhang, Yunfan Shi, Jiaming Zhang, Yulin Wan, Yuchuan Wang, Ying Zhang, Qiuyun Liu
Format: Article
Language:English
Published: SAGE Publishing 2020-06-01
Series:Journal of International Medical Research
Online Access:https://doi.org/10.1177/0300060520929853

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https://doi.org/10.1177/0300060520929853

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