iPSC-Derived Gaucher Macrophages Display Growth Impairment and Activation of Inflammation-Related Cell Death

iPSC-Derived Gaucher Macrophages Display Growth Impairment and Activation of Inflammation-Related Cell Death

Gaucher disease is a lysosomal storage disorder characterized by β-glucosidase enzyme deficiency and substrate accumulation, especially in cells of the reticuloendothelial system. Typical features of the disease are the unrestrained activation of inflammatory mechanisms, whose molecular pathways are...

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Bibliographic Details
Main Authors: Daria Messelodi, Salvatore Nicola Bertuccio, Valentina Indio, Silvia Strocchi, Alberto Taddia, Salvatore Serravalle, Jessica Bandini, Annalisa Astolfi, Andrea Pession
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
Gaucher disease
iPSC
macrophages
inflammation
necroptosis
Online Access:https://www.mdpi.com/2073-4409/10/11/2822

Internet

https://www.mdpi.com/2073-4409/10/11/2822

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