iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons

Summary: Motor neuron degeneration, the defining feature of amyotrophic lateral sclerosis (ALS), is a primary example of cell-type specificity in neurodegenerative diseases. Using isogenic pairs of induced pluripotent stem cells (iPSCs) harboring different familial ALS mutations, we assess the capac...

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Bibliographic Details
Main Authors:	Aaron Held, Michelle Adler, Christine Marques, Charles Jourdan Reyes, Amey S. Kavuturu, Ana R.A.A. Quadros, I. Sandra Ndayambaje, Erika Lara, Michael Ward, Clotilde Lagier-Tourenne, Brian J. Wainger
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Series:	Cell Reports
Subjects:	CP: Stem cell research CP: Neuroscience
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723010574

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http://www.sciencedirect.com/science/article/pii/S2211124723010574

iPSC motor neurons, but not other derived cell types, capture gene expression changes in postmortem sporadic ALS motor neurons

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