Advances in the allostery of angiotensin II type 1 receptor

Advances in the allostery of angiotensin II type 1 receptor

Abstract Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high selectivity and safety. However, no allost...

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Bibliographic Details
Main Authors: Xi Zhang, Suli Zhang, Meili Wang, Hao Chen, Huirong Liu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell & Bioscience
Subjects:
Angiotensin II type 1 receptor
Conformation
Allostery
Biased ligands
Dimers
Allosteric pocket
Online Access:https://doi.org/10.1186/s13578-023-01063-x

Internet

https://doi.org/10.1186/s13578-023-01063-x

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