Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination

Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination

Resistance to the last-line polymyxins is emerging in multidrug-resistant Klebsiella pneumoniae and phage therapy is a promising alternative. However, phage monotherapy often rapidly causes resistance and few studies have examined antibiotic-phage combinations against K. pneumoniae. Here, we investi...

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Bibliographic Details
Main Authors: Mei-Ling Han, Sue C. Nang, Yu-Wei Lin, Yan Zhu, Heidi H. Yu, Hasini Wickremasinghe, Christopher K. Barlow, Darren J. Creek, Simon Crawford, Gauri Rao, Chongshan Dai, Jeremy J. Barr, Kim Chan, Robert Turner Schooley, Tony Velkov, Jian Li
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Klebsiella pneumoniae
Polymyxin resistance
Bacteriophage
Metabolome
Central carbon metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022000071

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http://www.sciencedirect.com/science/article/pii/S2001037022000071

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