Effects of extracellular metabolic acidosis and out-of-equilibrium CO2/HCO3− solutions on intracellular pH in cultured rat hippocampal neurons

Effects of extracellular metabolic acidosis and out-of-equilibrium CO2/HCO3− solutions on intracellular pH in cultured rat hippocampal neurons

Metabolic acidosis (MAc)—an extracellular pH (pHo) decrease caused by a [HCO3−]o decrease at constant [CO2]o—usually causes intracellular pH (pHi) to fall. Here we determine the extent to which the pHi decrease depends on the pHo decrease vs the concomitant [HCO3−]o decrease. We use rapid-mixing to...

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Bibliografische gegevens
Hoofdauteurs: Patrice G. Bouyer, Ahlam I. Salameh, Yuehan Zhou, Tiffany N. Kolba, Walter F. Boron
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2024-10-01
Reeks:Frontiers in Physiology
Onderwerpen:
CO2/HCO3− out of equilibrium solutions
pH regulation
HCO3− sensor pHo sensor
acid base
neuron
Online toegang:https://www.frontiersin.org/articles/10.3389/fphys.2024.1434359/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2024.1434359/full

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