The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling

The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling

BackgroundA significant level of CD70 can be detected in various types of tumor tissues and CD27 is expressed on Treg cells, but CD70 expression is low in normal tissues. The interaction between CD70 and CD27 can stimulate the proliferation and survival of cancer cells and increase the level of solu...

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Bibliographic Details
Main Authors: Song Li, Dianze Chen, Huiqin Guo, Dandan Liu, Chunmei Yang, Ruliang Zhang, Tianxiang Wang, Fan Zhang, Xing Bai, Yanan Yang, Nana Sun, Wei Zhang, Li Zhang, Gui Zhao, Liang Peng, Xiaoping Tu, Wenzhi Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Oncology
Subjects:
IMM40H
CD70/CD27 signaling
CD70
targeting CD70 antibody
ADCC
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1240061/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1240061/full

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