Fragment length profiles of cancer mutations enhance detection of circulating tumor DNA in patients with early-stage hepatocellular carcinoma

Fragment length profiles of cancer mutations enhance detection of circulating tumor DNA in patients with early-stage hepatocellular carcinoma

Abstract Background Late detection of hepatocellular carcinoma (HCC) results in an overall 5-year survival rate of less than 16%. Liquid biopsy (LB) assays based on detecting circulating tumor DNA (ctDNA) might provide an opportunity to detect HCC early noninvasively. Increasing evidence indicates t...

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Main Authors: Van-Chu Nguyen, Trong Hieu Nguyen, Thanh Hai Phan, Thanh-Huong Thi Tran, Thu Thuy Thi Pham, Tan Dat Ho, Hue Hanh Thi Nguyen, Minh-Long Duong, Cao Minh Nguyen, Que-Tran Bui Nguyen, Hoai-Phuong Thi Bach, Van-Vu Kim, The-Anh Pham, Bao Toan Nguyen, Thanh Nhan Vo Nguyen, Le Anh Khoa Huynh, Vu Uyen Tran, Thuy Thi Thu Tran, Thanh Dang Nguyen, Dung Thai Bieu Phu, Boi Hoan Huu Phan, Quynh-Tho Thi Nguyen, Dinh-Kiet Truong, Thanh-Thuy Thi Do, Hoai-Nghia Nguyen, Minh-Duy Phan, Hoa Giang, Le Son Tran
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
Cell free DNA
Circulating tumor DNA
Liquid biopsy
Cancer specific mutation
Fragmentomics
Online Access:https://doi.org/10.1186/s12885-023-10681-0

Internet

https://doi.org/10.1186/s12885-023-10681-0

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