Computational Insight Into Vitamin K1 ω-Hydroxylation by Cytochrome P450 4F2

Computational Insight Into Vitamin K1 ω-Hydroxylation by Cytochrome P450 4F2

Vitamin K1 (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids. However, the mechanism of VK1 ω-hydroxylation...

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Bibliographic Details
Main Authors: Junhao Li, Hongxiao Zhang, Guixia Liu, Yun Tang, Yaoquan Tu, Weihua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
cytochrome P450
CYP4F2
ω-hydroxylation
molecular dynamics
QM/MM
homology modeling
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01065/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01065/full

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