Expanding N-glycopeptide identifications by modeling fragmentation, elution, and glycome connectivity

Abstract Accurate glycopeptide identification in mass spectrometry-based glycoproteomics is a challenging problem at scale. Recent innovation has been made in increasing the scope and accuracy of glycopeptide identifications, with more precise uncertainty estimates for each part of the structure. We...

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Bibliographic Details
Main Authors: Joshua Klein, Luis Carvalho, Joseph Zaia
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-50338-5