Successful application of virtual screening and molecular dynamics simulations against antimalarial molecular targets

Successful application of virtual screening and molecular dynamics simulations against antimalarial molecular targets

The main challenge in the control of malaria has been the emergence of drug-resistant parasites. The presence of drug-resistant Plasmodium sp. has raised the need for new antimalarial drugs. Molecular modelling techniques have been used as tools to develop new drugs. In this study, we employed virtu...

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Bibliographic Details
Main Authors: Renata Rachide Nunes, Marina dos Santos Costa, Bianca dos Reis Santos, Amanda Luisa da Fonseca, Lorena Sales Ferreira, Rafael Cesar Russo Chagas, Alisson Marques da Silva, Fernando de Pilla Varotti, Alex Gutterres Taranto
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ)
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Plasmodium falciparum
plasmepsin-II
plasmepsin-IV
falcipain-II
PfATP6
virtual screening
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016005023101&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016005023101&lng=en&tlng=en

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