SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Antagonizing DNMT1

SIRT6 Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells Through Antagonizing DNMT1

BackgroundAdipose-derived stem cells (ADSCs) are increasingly used in regenerative medicine because of their potential to differentiate into multiple cell types, including osteogenic lineages. Sirtuin protein 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase that plays imp...

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Bibliographic Details
Main Authors: Bo Jia, Jun Chen, Qin Wang, Xiang Sun, Jiusong Han, Fernando Guastaldi, Shijian Xiang, Qingsong Ye, Yan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
sirtuin proteins 6
osteogenic differentiation
adipose-derived mesenchymal stem cells
NOTCH signaling
DNMT1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.648627/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.648627/full

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