Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation–Contraction Coupling

Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation–Contraction Coupling

Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies and a leading cause of sudden cardiac death in young adults. Despite profound insights into the genetics, there is imperfect correlation between mutation and clinical prognosis, suggesting complex molecular cascades dri...

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Bibliographic Details
Main Authors: Jarrod Moore, Jourdan Ewoldt, Gabriela Venturini, Alexandre C. Pereira, Kallyandra Padilha, Matthew Lawton, Weiwei Lin, Raghuveera Goel, Ivan Luptak, Valentina Perissi, Christine E. Seidman, Jonathan Seidman, Michael T. Chin, Christopher Chen, Andrew Emili
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
hypertrophic cardiomyopathy
human induced pluripotent stem-cell-derived cardiomyocytes
myectomy
liquid chromatography–tandem mass spectrometry
phosphoproteomics
metabolomics
Online Access:https://www.mdpi.com/1422-0067/24/5/4724

Internet

https://www.mdpi.com/1422-0067/24/5/4724

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