Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model

Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model

Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas, for which no vaccines or antiviral agents have been approved. TC-83 and V3526 are the best-characterized vaccine candidates for VEEV. Both are live-attenuated vaccines and have been associated with safety concerns,...

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Bibliographic Details
Main Authors: Clint A. Haines, Rafael K. Campos, Sasha R. Azar, K. Lane Warmbrod, Tiffany F. Kautz, Naomi L. Forrester, Shannan L. Rossi
Format: Article
Language:English
Published: Compuscript Ltd 2022-01-01
Series:Zoonoses
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2021-0016

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https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2021-0016

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