An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER<sup>+</sup>) Breast Cancer: Effects on Sensitive and Resistant Cell Lines

An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER<sup>+</sup>) Breast Cancer: Effects on Sensitive and Resistant Cell Lines

Around 70–85% of all breast cancer (BC) cases are estrogen receptor-positive (ER<sup>+</sup>). The third generation of aromatase inhibitors (AIs) is the first-line treatment option for these tumors. Despite their therapeutic success, they induce several side effects and resistance, which...

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Bibliographic Details
Main Authors: Cristina Amaral, Georgina Correia-da-Silva, Cristina Ferreira Almeida, Maria João Valente, Carla Varela, Elisiário Tavares-da-Silva, Anne Marie Vinggaard, Natércia Teixeira, Fernanda M. F. Roleira
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
breast cancer
endocrine therapy
endocrine resistance
aromatase inhibitors
exemestane
oxymestane
Online Access:https://www.mdpi.com/1420-3049/28/2/789

Internet

https://www.mdpi.com/1420-3049/28/2/789

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