Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice

Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice

Abstract Background Globally, 1 in 11 adults have diabetes mellitus, and 90% of the cases are type 2 diabetes mellitus. Insulin resistance is a central defect in type 2 diabetes mellitus, and although multiple drugs have been developed to ameliorate insulin resistance, the limitations and accompanyi...

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Bibliographic Details
Main Authors: Guang Chen, Xiao-yan Fan, Xiao-peng Zheng, Yue-lei Jin, Ying Liu, Shuang-chun Liu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
HUC-MSCs
Insulin resistant
PTEN, crosstalk
PI3K/Akt
Erk/MAPK
Db/db mice
Online Access:http://link.springer.com/article/10.1186/s13287-020-01865-7

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http://link.springer.com/article/10.1186/s13287-020-01865-7

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