Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages

Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages

<p>Abstract</p> <p>Infiltration of Ly6C<sup>hi</sup> monocytes from the blood is a hallmark of viral encephalitis. In mice with lethal encephalitis caused by West Nile virus (WNV), an emerging neurotropic flavivirus, inhibition of Ly6C<sup>hi</sup> monocyte...

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Bibliographic Details
Main Authors: Getts Daniel R, Terry Rachael L, Getts Meghann Teague, Müller Marcus, Rana Sabita, Deffrasnes Celine, Ashhurst Thomas Myles, Radford Jane, Hofer Markus, Thomas Shane, Campbell Iain L, King Nicholas JC
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Journal of Neuroinflammation
Subjects:
Neurotropic virus
Flavivirus
Inflammatory monocytes
West Nile virus encephalitis
Macrophage infiltration
VLA-4
Integrins
Nitric oxide
Online Access:http://www.jneuroinflammation.com/content/9/1/246

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http://www.jneuroinflammation.com/content/9/1/246

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