Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis

Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis

Highly Pathogenic Avian Influenza Viruses (HPAIVs) arise from low pathogenic precursors following spillover from wild waterfowl into poultry populations. The main virulence determinant of HPAIVs is the presence of a multi-basic cleavage site (MBCS) in the hemagglutinin (HA) glycoprotein. The MBCS al...

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Bibliographic Details
Main Authors: Anja C. M. de Bruin, Mathis Funk, Monique I. Spronken, Alexander P. Gultyaev, Ron A. M. Fouchier, Mathilde Richard
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
Highly Pathogenic Avian Influenza Viruses
Low-Pathogenic Avian Influenza Viruses
multibasic cleavage site
virulence
pathogen evolution
proteolytic cleavage
Online Access:https://www.mdpi.com/1999-4915/14/7/1566

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https://www.mdpi.com/1999-4915/14/7/1566

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