Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer

Engineering and Characterization of a Fluorescent Native-Like HIV-1 Envelope Glycoprotein Trimer

Generation of a stable, soluble mimic of the HIV-1 envelope glycoprotein (Env) trimer on the virion surface has been considered an important first step for developing a successful HIV-1 vaccine. Recently, a soluble native-like Env trimer (BG505 SOSIP.664) has been described. This protein has facilit...

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Bibliographic Details
Main Authors: Kwinten Sliepen, Thijs van Montfort, Gabriel Ozorowski, Laura K. Pritchard, Max Crispin, Andrew B. Ward, Rogier W. Sanders
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Biomolecules
Subjects:
green fluorescent protein (GFP)
HIV-1 Env
SOSIP
superfolder GFP
protein engineering
Online Access:http://www.mdpi.com/2218-273X/5/4/2919

Internet

http://www.mdpi.com/2218-273X/5/4/2919

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