Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

Abstract In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy resistance. To promote nose-to-brain transport, w...

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Bibliographic Details
Main Authors: Matthias Van Woensel, Thomas Mathivet, Nathalie Wauthoz, Rémi Rosière, Abhishek D. Garg, Patrizia Agostinis, Véronique Mathieu, Robert Kiss, Florence Lefranc, Louis Boon, Jochen Belmans, Stefaan W. Van Gool, Holger Gerhardt, Karim Amighi, Steven De Vleeschouwer
Format: Article
Language:English
Published: Nature Portfolio 2017-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01279-1

Internet

https://doi.org/10.1038/s41598-017-01279-1

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