The glycolysis/HIF-1α axis defines the inflammatory role of IL-4-primed macrophages

The glycolysis/HIF-1α axis defines the inflammatory role of IL-4-primed macrophages

Summary: T helper type 2 (Th2) cytokine-activated M2 macrophages contribute to inflammation resolution and wound healing. This study shows that IL-4-primed macrophages exhibit a stronger response to lipopolysaccharide stimulation while maintaining M2 signature gene expression. Metabolic divergence b...

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Bibliographic Details
Main Authors: Buyun Dang, Qingxiang Gao, Lishan Zhang, Jia Zhang, Hanyi Cai, Yanhui Zhu, Qiumei Zhong, Junqiao Liu, Yujia Niu, Kairui Mao, Nengming Xiao, Wen-Hsien Liu, Shu-hai Lin, Jialiang Huang, Stanley Ching-Cheng Huang, Ping-Chih Ho, Shih-Chin Cheng
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Cell Reports
Subjects:
M2 macrophage
IL-4
epigenetics
glycolysis
Hif1α
trained immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723004825

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http://www.sciencedirect.com/science/article/pii/S2211124723004825

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