DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway

DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway

Hepatic fibrosis is caused by liver damage as a consequence of wound healing response. Recent studies have shown that hepatic fibrosis could be effectively reversed, partly through regression of activated hepatic stellate cells (HSCs). Transcription factor 21 (TCF21), a member of the basic helix-loo...

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Bibliographic Details
Main Authors: Liangyun Li, Shaoxi Diao, Zixiang Chen, Jintong Zhang, Wei Chen, Tianqi Wang, Xin Chen, Yuxin Zhao, Tao Xu, Cheng Huang, Jun Li
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Pharmacological Research
Subjects:
Hepatic fibrosis
DNMT3a
TCF21
HnRNPA1
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823001640

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http://www.sciencedirect.com/science/article/pii/S1043661823001640

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