Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis

Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis

The current study intended to delve into the mechanisms of dexmedetomidine (Dex) in regulating myocardial pyroptosis against myocardial ischemia/reperfusion injury (MIRI). The rat MIRI models were induced by ligation/release of the coronary artery in vivo and Langendorff perfusion ex vivo. Hemodynam...

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Bibliographic Details
Main Authors: Lingyan Wang, Jin Liu, Zhuoran Wang, Xi Qian, Yu Zhao, Quan Wang, Na Dai, Yuhan Xie, Weijun Zeng, Wei Yang, Xiangfeng Bai, Yuqiao Yang, Jinqiao Qian
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Dexmedetomidine
Myocardial ischemia/reperfusion injury
Pyroptosis
MiR-665
MEF2D
Nrf2
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010466

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http://www.sciencedirect.com/science/article/pii/S0753332223010466

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