CRISPR-Cas9 knockout screening identifies KIAA1429 as an essential gene in Ewing sarcoma

Abstract Background Ewing sarcoma (ES) is an aggressive childhood bone and soft tissue cancer. KIAA1429 is one type of N6-methyladenosine (m6A) writer that plays a tumor-progressive role in various cancers, but the role of KIAA1429 in ES remains to be elucidated. The aim of the study was to investig...

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Bibliographic Details
Main Authors: Kezhe Tan, Wenjie Lu, Feng Chen, Hao Shi, Yingxuan Ma, Zhou Chen, Wei Wu, Zhibao Lv, Jialin Mo
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-023-02828-5