Inhibition of AURKA kinase activity suppresses collective invasion in a microfluidic cell culture platform

Inhibition of AURKA kinase activity suppresses collective invasion in a microfluidic cell culture platform

Abstract Tumor local invasion is the first step of metastasis cascade which remains the key obstacle for cancer therapy. Collective cell migration plays a critical role in tumor invading into surrounding tissues. In vitro assays fail to assess collective invasion in a real time manner. Herein we aim...

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Bibliographic Details
Main Authors: Jiang-Long Xia, Wen-Jun Fan, Fei-Meng Zheng, Wen-Wen Zhang, Jia-Jun Xie, Meng-Ying Yang, Muhammad Kamran, Peng Wang, Hong-Ming Teng, Chun-Li Wang, Quentin Liu
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02623-1

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https://doi.org/10.1038/s41598-017-02623-1

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