Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin

The auto-inhibited, super-relaxed (SRX) state of cardiac myosin is thought to be crucial for regulating contraction, relaxation, and energy conservation in the heart. We used single ATP turnover experiments to demonstrate that a dilated cardiomyopathy (DCM) mutation (E525K) in human beta-cardiac myo...

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Bibliographic Details
Main Authors: David V Rasicci, Prince Tiwari, Skylar ML Bodt, Rohini Desetty, Fredrik R Sadler, Sivaraj Sivaramakrishnan, Roger Craig, Christopher M Yengo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
cardiac muscle myosin
FRET
super-relaxed state
interacting-heads motif
dilated cardiomyopathy
Online Access:https://elifesciences.org/articles/77415

Internet

https://elifesciences.org/articles/77415

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