Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis

Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis

Abstract Fibroblast activation including proliferation, survival, and ECM production is central to initiation and maintenance of fibrotic lesions in idiopathic pulmonary fibrosis (IPF). However, druggable molecules that target fibroblast activation remain limited. In this study, we show that multipl...

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Bibliographic Details
Main Authors: Rajesh K Kasam, Sudhir Ghandikota, Divyalakshmi Soundararajan, Geereddy B Reddy, Steven K Huang, Anil G Jegga, Satish K Madala
Format: Article
Language:English
Published: Springer Nature 2020-09-01
Series:EMBO Molecular Medicine
Subjects:
Aurora Kinase B
Barasertib
fibroproliferation
pulmonary fibrosis
Wilms’ tumor 1
Online Access:https://doi.org/10.15252/emmm.202012131

Internet

https://doi.org/10.15252/emmm.202012131

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