Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice

Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice

Abstract Background Neuroinflammation has been identified as one of the primary pathogenic factors of neuropsychiatric systemic lupus erythematosus (NPSLE). However, there are no dedicated treatments available in clinics to alleviate neuroinflammation in NPSLE. It has been proposed that stimulating...

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Bibliographic Details
Main Authors: Yang Yun, Xuejiao Wang, Jingyi Xu, Jingyu Chen, Xueru Wang, Pingting Yang, Ling Qin
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Behavioral and Brain Functions
Subjects:
Basal forebrain
Cholinergic anti-inflammatory effect
Neuroinflammation
Neuropsychiatric lupus
Behavioral deficits
Optogenetics
Online Access:https://doi.org/10.1186/s12993-023-00213-y

Internet

https://doi.org/10.1186/s12993-023-00213-y

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