Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase

Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase

Multidrug-resistant (MDR) Gram-negative bacteria have become a global threat to human life and health, and novel antibiotics are urgently needed. The thioredoxin (Trx) system can be used as an antibacterial target to combat MDR bacteria. Here, we found that two active gold(I) selenium N-heterocyclic...

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Bibliographic Details
Main Authors: Xiuli Chen, Shibo Sun, Sheng Huang, Han Yang, Qing Ye, Lin Lv, Yanshan Liang, Jinjun Shan, Jianqiang Xu, Wukun Liu, Tonghui Ma
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Redox Biology
Subjects:
N-heterocyclic carbine
Gold(I) complexes
Thioredoxin reductase
Reactive oxygen species
Drug-resistant bacteria
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000228

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http://www.sciencedirect.com/science/article/pii/S2213231723000228

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