Antigen Specificity Enhances Disease Control by Tregs in Vitiligo

Antigen Specificity Enhances Disease Control by Tregs in Vitiligo

Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs can provide protection against depigmentation. Ganglioside D3 (GD3) is overexpressed by perilesional epidermal cells...

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Bibliographic Details
Main Authors: Zhussipbek Mukhatayev, Emilia R. Dellacecca, Cormac Cosgrove, Rohan Shivde, Dinesh Jaishankar, Katherine Pontarolo-Maag, Jonathan M. Eby, Steven W. Henning, Yekaterina O. Ostapchuk, Kettil Cedercreutz, Alpamys Issanov, Shikhar Mehrotra, Andreas Overbeck, Richard P. Junghans, Joseph R. Leventhal, I. Caroline Le Poole
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
vitiligo
regulatory T cells
chimeric antigen receptor T cells
ganglioside D3
antigen-specific Treg
autoimmune diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.581433/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.581433/full

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