ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer

ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer

Cancer-associated fibroblasts (CAFs) have been implicated in lung cancer chemo-resistance. Here the authors show that a zinc-transporter positive CAF subset is enriched in lung cancer models after chemotherapy and actively transfers zinc to cancer cells, promoting ABCB1-mediated chemo-resistance.

Bibliographic Details
Main Authors: Chen Ni, Xiaohan Lou, Xiaohan Yao, Linlin Wang, Jiajia Wan, Xixi Duan, Jialu Liang, Kaili Zhang, Yuanyuan Yang, Li Zhang, Chanjun Sun, Zhenzhen Li, Ming Wang, Linyu Zhu, Dekang Lv, Zhihai Qin
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33521-4

Internet

https://doi.org/10.1038/s41467-022-33521-4

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