Germline variation of Ribonuclease H2 genes in ovarian cancer patients

Germline variation of Ribonuclease H2 genes in ovarian cancer patients

Abstract Epithelial ovarian carcinoma (EOC) is a genetically heterogeneous disease that is partly driven by molecular defects in mismatch repair (MMR) or homology-directed DNA repair (HDR). Ribonuclease H2 serves to remove mis-incorporated ribonucleotides from DNA which alleviates HDR mechanisms and...

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Bibliographic Details
Main Authors: Rahel Polaczek, Peter Schürmann, Lisa-Marie Speith, Robert Geffers, Matthias Dürst, Peter Hillemanns, Tjoung-Won Park-Simon, Clemens Liebrich, Thilo Dörk
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Ovarian Research
Subjects:
RNase H2
Ribonucleotide excision repair
Homologous recombination
MMR deficiency
Platinum resistance
Epithelial ovarian carcinoma
Online Access:https://doi.org/10.1186/s13048-020-00753-1

Internet

https://doi.org/10.1186/s13048-020-00753-1

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