Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea

Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea

Abstract Background Inner ear hair cells as mechanoreceptors are extremely important for hearing. Defects in hair cells are a major cause of deafness. Induced pluripotent stem cells (iPSCs) are promising for regenerating inner ear hair cells and treating hearing loss. Here, we investigated migration...

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Bibliographic Details
Main Authors: Jianling Chen, Fanfan Hong, Cui Zhang, Liang Li, Cuicui Wang, Haosong Shi, Yong Fu, Jinfu Wang
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Stem Cell Research & Therapy
Subjects:
Sensorineural hearing loss
Induced pluripotent stem cells
Hair cell-like cells
Otic epithelial progenitors
Synaptic connection
Online Access:http://link.springer.com/article/10.1186/s13287-018-0967-1

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http://link.springer.com/article/10.1186/s13287-018-0967-1

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