Simultaneous Determination of 6-Mercaptopurine and its Oxidative Metabolites in Synthetic Solutions and Human Plasma using Spectrophotometric Multivariate Calibration Methods

Simultaneous Determination of 6-Mercaptopurine and its Oxidative Metabolites in Synthetic Solutions and Human Plasma using Spectrophotometric Multivariate Calibration Methods

Introduction: 6-Mercaptopurine (6MP) is an important chemotherapeutic drug in the conventional treatment of childhood acute lymphoblastic leukemia (ALL). It is catabolized to 6-thiouric acid (6TUA) through 8-hydroxo-6-mercaptopurine (8OH6MP) or 6-thioxanthine (6TX) intermediates. Methods: High-perfo...

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Bibliographic Details
Main Authors: Mohammad-Reza Rashidi, Davoud Asgari, Abdolhossein Naseri, Kaveh Amini, Mohammad-Yaser Khani, Mohammad-Hossein Sorouraddin
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2011-06-01
Series:BioImpacts
Subjects:
6-Mercaptopurine
Oxidative Metabolites
Multivariate
Spectrophotometric
Online Access:http://dx.doi.org/10.5681/bi.2011.008

Internet

http://dx.doi.org/10.5681/bi.2011.008

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