KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway

KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway

Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is active in the phenotypic switch that occurs during astrogliosis in Alzheimer's disease and ischemic stroke. Here, transcriptome sequencing...

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Bibliographic Details
Main Authors: Tianjiao Wei, Yanxia Wang, Weirong Xu, Yan Liu, Hongzhuan Chen, Zhihua Yu
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Neurobiology of Disease
Subjects:
KCa3.1
Orai1
Astrocytes
Insulin
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302566

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http://www.sciencedirect.com/science/article/pii/S0969996119302566

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