Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine
<p>Abstract</p> <p>Background</p> <p>Although the systemic administration of cannabinoids produces antinociception, their chronic use leads to analgesic tolerance as well as cross-tolerance to morphine. These effects are mediated by cannabinoids binding to peripheral, s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-03-01
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| Series: | Molecular Pain |
| Online Access: | http://www.molecularpain.com/content/5/1/11 |