TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury

TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury

Highlights Following in vitro ischemia, the nerve growth factor receptor TrkB is activated in the presence of the TrkB agonist 7,8-DHF only in female and not in male cultured hippocampal neurons, leading to increased neuronal survival. Expression of ERα is increased following in vitro ischemia in fe...

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Bibliographic Details
Main Authors: Vishal Chanana, Dila Zafer, Douglas B Kintner, Jayadevi H Chandrashekhar, Jens Eickhoff, Peter A Ferrazzano, Jon E Levine, Pelin Cengiz
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Biology of Sex Differences
Subjects:
Neurotrophin receptor
Estrogen receptor alpha
Neonatal
Hypoxia ischemia
7,8-dihydroxyflavone
Tyrosine kinase B receptor
Online Access:https://doi.org/10.1186/s13293-024-00596-1

Internet

https://doi.org/10.1186/s13293-024-00596-1

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