TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
Highlights Following in vitro ischemia, the nerve growth factor receptor TrkB is activated in the presence of the TrkB agonist 7,8-DHF only in female and not in male cultured hippocampal neurons, leading to increased neuronal survival. Expression of ERα is increased following in vitro ischemia in fe...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13293-024-00596-1 |
| _version_ | 1827291763092488192 |
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| author | Vishal Chanana Dila Zafer Douglas B Kintner Jayadevi H Chandrashekhar Jens Eickhoff Peter A Ferrazzano Jon E Levine Pelin Cengiz |
| author_facet | Vishal Chanana Dila Zafer Douglas B Kintner Jayadevi H Chandrashekhar Jens Eickhoff Peter A Ferrazzano Jon E Levine Pelin Cengiz |
| author_sort | Vishal Chanana |
| collection | DOAJ |
| description | Highlights Following in vitro ischemia, the nerve growth factor receptor TrkB is activated in the presence of the TrkB agonist 7,8-DHF only in female and not in male cultured hippocampal neurons, leading to increased neuronal survival. Expression of ERα is increased following in vitro ischemia in female but not male hippocampal neurons. The female hippocampal neuronal specific responses to in vitro ischemia are blocked by pre-treatment with testosterone. The data support a model for a female-specific a neuroprotective pathway in hippocampal neurons. The pathway is activated by a TrkB agonist, dependent on ERα and blocked by testosterone. |
| first_indexed | 2024-04-24T12:43:22Z |
| format | Article |
| id | doaj.art-2aaecf1bf5a04f54a212a65447592556 |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-04-24T12:43:22Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-2aaecf1bf5a04f54a212a654475925562024-04-07T11:06:11ZengBMCBiology of Sex Differences2042-64102024-04-0115111610.1186/s13293-024-00596-1TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injuryVishal Chanana0Dila Zafer1Douglas B Kintner2Jayadevi H Chandrashekhar3Jens Eickhoff4Peter A Ferrazzano5Jon E Levine6Pelin Cengiz7Waisman Center, University of WisconsinWaisman Center, University of WisconsinWaisman Center, University of WisconsinWaisman Center, University of WisconsinDepartment of Statistics and Bioinformatics, University of Wisconsin School of Medicine and Public HealthWaisman Center, University of WisconsinDepartment of Neuroscience, University of WisconsinWaisman Center, University of WisconsinHighlights Following in vitro ischemia, the nerve growth factor receptor TrkB is activated in the presence of the TrkB agonist 7,8-DHF only in female and not in male cultured hippocampal neurons, leading to increased neuronal survival. Expression of ERα is increased following in vitro ischemia in female but not male hippocampal neurons. The female hippocampal neuronal specific responses to in vitro ischemia are blocked by pre-treatment with testosterone. The data support a model for a female-specific a neuroprotective pathway in hippocampal neurons. The pathway is activated by a TrkB agonist, dependent on ERα and blocked by testosterone.https://doi.org/10.1186/s13293-024-00596-1Neurotrophin receptorEstrogen receptor alphaNeonatalHypoxia ischemia7,8-dihydroxyflavoneTyrosine kinase B receptor |
| spellingShingle | Vishal Chanana Dila Zafer Douglas B Kintner Jayadevi H Chandrashekhar Jens Eickhoff Peter A Ferrazzano Jon E Levine Pelin Cengiz TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury Biology of Sex Differences Neurotrophin receptor Estrogen receptor alpha Neonatal Hypoxia ischemia 7,8-dihydroxyflavone Tyrosine kinase B receptor |
| title | TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury |
| title_full | TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury |
| title_fullStr | TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury |
| title_full_unstemmed | TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury |
| title_short | TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury |
| title_sort | trkb mediated neuroprotection in female hippocampal neurons is autonomous estrogen receptor alpha dependent and eliminated by testosterone a proposed model for sex differences in neonatal hippocampal neuronal injury |
| topic | Neurotrophin receptor Estrogen receptor alpha Neonatal Hypoxia ischemia 7,8-dihydroxyflavone Tyrosine kinase B receptor |
| url | https://doi.org/10.1186/s13293-024-00596-1 |
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