Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

Abstract Background Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration of novel ther...

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Bibliographic Details
Main Authors: Penghui Wei, Min Jia, Xiangyi Kong, Wenyuan Lyu, Hao Feng, Xinyi Sun, Jianjun Li, Jian-jun Yang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Stem Cell Research & Therapy
Subjects:
Human umbilical cord-derived mesenchymal stem cells
Cognitive impairment
Aging brain
Perioperative neurocognitive disorder
BDNF/TrkB
Lipid metabolism
Online Access:https://doi.org/10.1186/s13287-023-03499-x

Internet

https://doi.org/10.1186/s13287-023-03499-x

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