Mesenchymal stem cell engineering by ARCA analog-capped mRNA

Mesenchymal stem cell engineering by ARCA analog-capped mRNA

We previously have shown that mRNA-based engineering may enhance mesenchymal stem cell (MSC) trafficking. However, optimal conditions for in vitro mRNA engineering of MSCs are unknown. Here, we investigated several independent variables: (1) transfection factor (Lipofectamine 2000 vs. TransIT), (2)...

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Bibliographic Details
Main Authors: Anna Andrzejewska, Renata Grzela, Anna Stankiewicz-Drogon, Piotr Rogujski, Siranjeevi Nagaraj, Edward Darzynkiewicz, Barbara Lukomska, Miroslaw Janowski
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: oligonucleotides: therapies and applications
mesenchymal stem cells
mRNA transfection
ARCA-cap analogs
metabolic activity
immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123001798

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http://www.sciencedirect.com/science/article/pii/S2162253123001798

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