Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

Abstract L-type voltage-gated calcium channels are involved in multiple physiological functions. Currently available antagonists do not discriminate between L-type channel isoforms. Importantly, no selective blocker is available to dissect the role of L-type isoforms Cav1.2 and Cav1.3 that are conco...

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Bibliographic Details
Main Authors: Pietro Mesirca, Jean Chemin, Christian Barrère, Eleonora Torre, Laura Gallot, Arnaud Monteil, Isabelle Bidaud, Sylvie Diochot, Michel Lazdunski, Tuck Wah Soong, Stéphanie Barrère-Lemaire, Matteo E. Mangoni, Joël Nargeot
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43502-w

Internet

https://doi.org/10.1038/s41467-023-43502-w

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