Bacillus subtilis produces (p)ppGpp in response to the bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect

Abstract Antibiotics combat bacteria through their bacteriostatic (by growth inhibition) or bactericidal (by killing bacteria) action. Mechanistically, it has been proposed that bactericidal antibiotics trigger cellular damage, while bacteriostatic antibiotics suppress cellular metabolism. Here, we...

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Bibliographic Details
Main Authors: Jin Yang, Jessica T. Barra, Danny K. Fung, Jue D. Wang
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:mLife
Subjects:
Online Access:https://doi.org/10.1002/mlf2.12031