Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A
In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The resu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/12/14522 |
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| author | Wen-Long Wang Hai-Jun Chen Wei-Ping Ma Min Gu Min-Zhi Fan Jing-Ya Li Bainian Feng Fa-Jun Nan |
| author_facet | Wen-Long Wang Hai-Jun Chen Wei-Ping Ma Min Gu Min-Zhi Fan Jing-Ya Li Bainian Feng Fa-Jun Nan |
| author_sort | Wen-Long Wang |
| collection | DOAJ |
| description | In order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The results showed that these replacements not only changed the conformational relationship between the 4,2-bisheterocycle tandem pair and the third heterocycle, but also had dramatic effect on its activity against influenza virus A. |
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| format | Article |
| id | doaj.art-2abd9cbb86384fa78bec7322c8109fcb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-20T10:08:01Z |
| publishDate | 2012-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2abd9cbb86384fa78bec7322c8109fcb2022-12-21T19:44:12ZengMDPI AGMolecules1420-30492012-12-011712145221453010.3390/molecules171214522Synthesis and Antiviral Activity of Conformational Analogues of Leucamide AWen-Long WangHai-Jun ChenWei-Ping MaMin GuMin-Zhi FanJing-Ya LiBainian FengFa-Jun NanIn order to study the effect of heterocyclic core conformational state of leucamide A on its anti-influenza virus A activity, five conformational analogues were prepared by replacing the Pro-Leu dipeptide in the molecule with various amino acids. The amino acids used were of 2 to 6 carbons. The results showed that these replacements not only changed the conformational relationship between the 4,2-bisheterocycle tandem pair and the third heterocycle, but also had dramatic effect on its activity against influenza virus A.http://www.mdpi.com/1420-3049/17/12/14522&#160leucamide Aconformational analoguessynthesisanti-influenza virus A |
| spellingShingle | Wen-Long Wang Hai-Jun Chen Wei-Ping Ma Min Gu Min-Zhi Fan Jing-Ya Li Bainian Feng Fa-Jun Nan Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A Molecules &#160 leucamide A conformational analogues synthesis anti-influenza virus A |
| title | Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A |
| title_full | Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A |
| title_fullStr | Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A |
| title_full_unstemmed | Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A |
| title_short | Synthesis and Antiviral Activity of Conformational Analogues of Leucamide A |
| title_sort | synthesis and antiviral activity of conformational analogues of leucamide a |
| topic | &#160 leucamide A conformational analogues synthesis anti-influenza virus A |
| url | http://www.mdpi.com/1420-3049/17/12/14522 |
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