Study protocol of a single-arm phase 2 study evaluating the preventive effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in colorectal cancer patients receiving adjuvant chemotherapy with capecitabine plus oxaliplatin (T-CRACC study)

Study protocol of a single-arm phase 2 study evaluating the preventive effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in colorectal cancer patients receiving adjuvant chemotherapy with capecitabine plus oxaliplatin (T-CRACC study)

Abstract Backgrounds Clinical evidence of the preventive effectiveness of medium-class topical corticosteroids for capecitabine-induced hand foot syndrome (HFS) is limited. Although the pathogenesis and mechanism of HFS are unclear, inflammatory reactions are thought to be involved in HFS developmen...

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Bibliographic Details
Main Authors: Yohei Iimura, Naoki Furukawa, Masaaki Ishibashi, Yuka Ahiko, Taro Tanabe, Susumu Aikou, Dai Shida, Masanori Nojima, Seiichiro Kuroda, Narikazu Boku
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Gastroenterology
Subjects:
Capecitabine
Hand foot syndrome
Medium class topical corticosteroid
Prevention
Online Access:https://doi.org/10.1186/s12876-022-02411-w

Internet

https://doi.org/10.1186/s12876-022-02411-w

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