Cooperative interaction of interferon regulatory factor -1 and bromodomain—containing protein 4 on RNA polymerase activation for intrinsic innate immunity

Cooperative interaction of interferon regulatory factor -1 and bromodomain—containing protein 4 on RNA polymerase activation for intrinsic innate immunity

IntroductionThe human orthopneumovirus, Respiratory Syncytial Virus (RSV), is the causative agent of severe lower respiratory tract infections (LRTI) and exacerbations of chronic lung diseases. In immune competent hosts, RSV productively infects highly differentiated epithelial cells, where it elici...

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Bibliographic Details
Main Authors: Xiaofang Xu, Dianhua Qiao, Allan R. Brasier
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
RSV
transcriptional elongation
RNA pol II
small airway basal cells
multipotent stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1366235/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1366235/full

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