Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.

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<h4>Background</h4>The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account. This study investiga...

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Bibliographic Details
Main Authors: Anoek L I van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A M Dekker, Marjolein R A van der Steen, Joris J T H Roelofs, Matijs van Meurs, Grietje Molema, Charissa E van den Brom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293673&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293673&type=printable

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