A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

The complex pathogenesis of osteoporosis includes excessive bone resorption, insufficient bone formation and inadequate vascularization, a combination which is difficult to completely address with conventional therapies. Engineered exosomes carrying curative molecules show promise as alternative ost...

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Bibliographic Details
Main Authors: Yongzhi Cui, Yuanyuan Guo, Li Kong, Jingyu Shi, Ping Liu, Rui Li, Yongtao Geng, Weihang Gao, Zhiping Zhang, Dehao Fu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-04-01
Series:Bioactive Materials
Subjects:
Exosomes
MSCs
siRNA
Bone targeting peptide
Osteoporosis therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21004333

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http://www.sciencedirect.com/science/article/pii/S2452199X21004333

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