Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women
<p>Abstract</p> <p>Background</p> <p>Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-11-01
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| Series: | Nutrition Journal |
| Subjects: | |
| Online Access: | http://www.nutritionj.com/content/11/1/98 |
| _version_ | 1811320056582242304 |
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| author | Klempel Monica C Kroeger Cynthia M Bhutani Surabhi Trepanowski John F Varady Krista A |
| author_facet | Klempel Monica C Kroeger Cynthia M Bhutani Surabhi Trepanowski John F Varady Krista A |
| author_sort | Klempel Monica C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown.</p> <p>Objective</p> <p>This study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk.</p> <p>Methods</p> <p>Obese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period.</p> <p>Results</p> <p>Body weight decreased more (P = 0.04) in the IFCR-L group (3.9 ± 1.4 kg) versus the IFCR-F group (2.5 ± 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 ± 1.2 kg and 1.9 ± 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 ± 0.5 kg) and IFCR-F (0.3 ± 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (<it>P</it> = 0.04) in the IFCR-L (19 ± 10%; 20 ± 9%, respectively) versus the IFCR-F group (8 ± 3%; 7 ± 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only.</p> <p>Conclusion</p> <p>These findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk.</p> |
| first_indexed | 2024-04-13T12:52:46Z |
| format | Article |
| id | doaj.art-2ac668ee45ef4a768403f4eb80992603 |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-04-13T12:52:46Z |
| publishDate | 2012-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-2ac668ee45ef4a768403f4eb809926032022-12-22T02:46:09ZengBMCNutrition Journal1475-28912012-11-011119810.1186/1475-2891-11-98Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese womenKlempel Monica CKroeger Cynthia MBhutani SurabhiTrepanowski John FVarady Krista A<p>Abstract</p> <p>Background</p> <p>Intermittent fasting (IF; severe restriction 1 d/week) facilitates weight loss and improves coronary heart disease (CHD) risk indicators. The degree to which weight loss can be enhanced if IF is combined with calorie restriction (CR) and liquid meals, remains unknown.</p> <p>Objective</p> <p>This study examined the effects of IF plus CR (with or without a liquid diet) on body weight, body composition, and CHD risk.</p> <p>Methods</p> <p>Obese women (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet. The trial had two phases: 1) 2-week weight maintenance period, and 2) 8-week weight loss period.</p> <p>Results</p> <p>Body weight decreased more (P = 0.04) in the IFCR-L group (3.9 ± 1.4 kg) versus the IFCR-F group (2.5 ± 0.6 kg). Fat mass decreased similarly (P < 0.0001) in the IFCR-L and IFCR-F groups (2.8 ± 1.2 kg and 1.9 ± 0.7 kg, respectively). Visceral fat was reduced (P < 0.001) by IFCR-L (0.7 ± 0.5 kg) and IFCR-F (0.3 ± 0.5 kg) diets. Reductions in total and LDL cholesterol levels were greater (<it>P</it> = 0.04) in the IFCR-L (19 ± 10%; 20 ± 9%, respectively) versus the IFCR-F group (8 ± 3%; 7 ± 4%, respectively). LDL peak particle size increased (P < 0.01), while heart rate, glucose, insulin, and homocysteine decreased (P < 0.05), in the IFCR-L group only.</p> <p>Conclusion</p> <p>These findings suggest that IF combined with CR and liquid meals is an effective strategy to help obese women lose weight and lower CHD risk.</p>http://www.nutritionj.com/content/11/1/98Intermittent fastingCalorie restrictionLiquid dietBody weightVisceral fatCholesterolCoronary heart diseaseObese women |
| spellingShingle | Klempel Monica C Kroeger Cynthia M Bhutani Surabhi Trepanowski John F Varady Krista A Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women Nutrition Journal Intermittent fasting Calorie restriction Liquid diet Body weight Visceral fat Cholesterol Coronary heart disease Obese women |
| title | Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women |
| title_full | Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women |
| title_fullStr | Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women |
| title_full_unstemmed | Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women |
| title_short | Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women |
| title_sort | intermittent fasting combined with calorie restriction is effective for weight loss and cardio protection in obese women |
| topic | Intermittent fasting Calorie restriction Liquid diet Body weight Visceral fat Cholesterol Coronary heart disease Obese women |
| url | http://www.nutritionj.com/content/11/1/98 |
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