Hypoxia‐Inducible Factor‐2α Signaling in the Skeletal System

ABSTRACT Hypoxia‐inducible factors (HIFs) are oxygen‐dependent heterodimeric transcription factors that mediate molecular responses to reductions in cellular oxygen (hypoxia). HIF signaling involves stable HIF‐β subunits and labile, oxygen‐sensitive HIF‐α subunits. Under hypoxic conditions, the HIF‐...

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Bibliographic Details
Main Authors: Sarah V Mendoza, Damian C Genetos, Clare E Yellowley
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:JBMR Plus
Subjects:
Online Access:https://doi.org/10.1002/jbm4.10733